Create a new rule. Rules can be anything. If a player fails to follow the rule, they must drink. This rule remains in effect until another Rule Card is drawn. Note - a rule can be trumped by a wielder of an Asshole/God card.
The last person to touch the floor after this card is drawn must drink.
Going around the circle, each player must ask the drawer of the card a question. If the drawer refuses to answer, they must drink.
Fill in the blank with a rule of your very own.
You are now the "Question Master". Any time you ask another player a question, if that player answers it, they must drink.
Starting with the drawer of this card, go around the circle alternating saying "Fuzzy Duck" and "Ducky Fuzz". If someone says "Duzzy Fuck", they must drink and the round ends.
Fill in the blank with a house rule.
Choose a word. Starting to the left, all players go around the circle saying words that rhyme with the original. No word can be said twice. The first player to fail to say a word or who says a word that doesn't rhyme must take a drink.
Place an empty cup in the center of the circle. Any time this card (traditionally the King) is drawn, the drawer pours some of their own drink into the center cup. When the fourth card is drawn, that player must chug the contents of the center cup.
Little Green Man
You must remove an imaginary little man from your cup every time you drink, and put him back after. If another player catches you failing to do so, you must drink again.
Take off your clothes.
You are now the "Thumb Master". Any time you place your thumb on the table, every other player must immediately place their thumb on the table as well. The last person to do so must take a drink. This can be done repeatedly until another thumb card is drawn.
Stand on one foot until your next turn, or take one drink.